Mechanically interlocked molecules for Biological Applications

Research in the Saady Group focuses on the design and synthesis of mechanically interlocked molecules (MIMs) for biological applications, with a particular emphasis on cyclodextrin-based rotaxanes. These unique architectures offer precise control over molecular motion and recognition, enabling new strategies for targeted delivery, sensing, and modulation of biological systems. Our work explores how the dynamic nature of interlocked systems can be harnessed to interact with complex biological environments in a controlled and functional manner. 

Selective Sensors for Biological Targets

We develop highly selective molecular sensors for biologically relevant targets. Our goal is to create systems capable of sensitive and specific detection in complex environments, contributing to advances in diagnostics and biomedical research. By combining supramolecular recognition with functional signal outputs, we aim to design next-generation sensing platforms that can operate efficiently in real biological settings. 

Simplifying the Synthesis of Heterocyclic Compounds

We are also interested in developing simplified and efficient synthetic methodologies for the construction of diverse heterocyclic compounds, which are central to pharmaceuticals, materials, and bioactive molecules. Our approach focuses on starting from readily available and inexpensive building blocks, reducing synthetic complexity, and improving accessibility. By streamlining reaction pathways and minimizing steps, we aim to enable practical, scalable routes to important molecular frameworks.